Functional connectivity of amygdala subnuclei in PTSD: a narrative review

EM Haris, RA Bryant, T Williamson… - Molecular …, 2023 - nature.com
While the amygdala is often implicated in the neurobiology of posttraumatic stress disorder
(PTSD), the pattern of results remains mixed. One reason for this may be the heterogeneity …

Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

P Cao, C Chen, A Liu, Q Shan, X Zhu, C Jia, X Peng… - Neuron, 2021 - cell.com
Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Understanding the dynamic and destiny of memories

L de Oliveira Alvares, FH Do-Monte - Neuroscience & Biobehavioral …, 2021 - Elsevier
Memory formation enables the retention of life experiences overtime. Based on previously
acquired information, organisms can anticipate future events and adjust their behaviors to …

Genetically identified amygdala–striatal circuits for valence-specific behaviors

X Zhang, W Guan, T Yang, A Furlan, X **ao, K Yu… - Nature …, 2021 - nature.com
The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with
either positive or negative valence, but how it processes motivationally opposing information …

Estimation of current and future physiological states in insular cortex

Y Livneh, AU Sugden, JC Madara, RA Essner… - Neuron, 2020 - cell.com
Interoception, the sense of internal bodily signals, is essential for physiological homeostasis,
cognition, and emotions. While human insular cortex (InsCtx) is implicated in interoception …

[HTML][HTML] Amygdala reward neurons form and store fear extinction memory

X Zhang, J Kim, S Tonegawa - Neuron, 2020 - cell.com
The ability to extinguish conditioned fear memory is critical for adaptive control of fear
response, and its impairment is a hallmark of emotional disorders like post-traumatic stress …

Prefrontal circuits encode both general danger and specific threat representations

M Martin-Fernandez, AP Menegolla… - Nature …, 2023 - nature.com
Behavioral adaptation to potential threats requires both a global representation of danger to
prepare the organism to react in a timely manner but also the identification of specific …

Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala

R Nguyen, K Koukoutselos, T Forro, S Ciocchi - Science Advances, 2023 - science.org
Extinction memory retrieval is influenced by spatial contextual information that determines
responding to conditioned stimuli (CS). However, it is poorly understood whether contextual …

Plastic and stimulus-specific coding of salient events in the central amygdala

T Yang, K Yu, X Zhang, X **ao, X Chen, Y Fu, B Li - Nature, 2023 - nature.com
The central amygdala (CeA) is implicated in a range of mental processes including attention,
motivation, memory formation and extinction and in behaviours driven by either aversive or …

Holographic stimulation of opposing amygdala ensembles bidirectionally modulates valence-specific behavior via mutual inhibition

SC Piantadosi, ZC Zhou, C Pizzano, CE Pedersen… - Neuron, 2024 - cell.com
The basolateral amygdala (BLA) is an evolutionarily conserved brain region, well known for
valence processing. Despite this central role, the relationship between activity of BLA …