Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …

While the cellular mechanisms of liver regeneration have been thoroughly studied, the role
of extracellular matrix (ECM) in liver regeneration is still poorly understood. We utilized a …

The extracellular matrix (ECM) provides structural support and imparts a wide variety of
environmental cues to cells. In the past decade, a growing body of work revealed that the …

The tumor microenvironment (TME) is a complex macromolecular network filled with a series
of stromal cells. It plays an important role in tumorigenesis, development, immune escape …

Tendon is a dense connective tissue that transmits high mechanical forces from skeletal
muscle to bone. The transcription factor scleraxis (Scx) is a highly specific marker of both …

Introduction: The lysyl oxidase family of enzymes is classically known as being required for
connective tissue maturation by oxidizing lysine residues in elastin and lysine and …

Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the
gastrointestinal tract. A severe complication of CD is fibrosis-associated strictures, which can …

Abstract Lysyl oxidase-like 2 (LOXL2) is an extracellular copper-dependent enzyme that
plays a central role in fibrosis by catalyzing the crosslinking and deposition of collagen …