The glycoproteome remains severely understudied because of significant analytical
challenges associated with glycoproteomics, the system-wide analysis of intact …

Mass spectrometry-based proteomics has evolved as a high-throughput research field over
the past decade. Significant advances in instrumentation, and the ability to produce huge …

Despite the clear association between myocardial injury, heart failure and depressed
myocardial energetics, little is known about upstream signals responsible for remodeling …

The precise quantification of changes between various physiological states in a biological
system is highly complex in nature. Over the past few years, in combination with classical …

Cyanobacteria have shaped the earth's biosphere as the first oxygenic photoautotrophs and
still play an important role in many ecosystems. The ability to adapt to changing …

Centrioles are evolutionarily conserved macromolecular structures that are fundamental to
form cilia, flagella, and centrosomes. Centrioles are 9-fold symmetrical microtubule-based …

Stable isotope dimethyl labeling, a widely used method for quantitative proteomics, was
extended to five channels for the first time. Comprehensive proteome and phosphoproteome …

Information on gene clusters for natural product biosynthesis is accumulating rapidly
because of the current boom of available genome sequencing data. However, linking a …

Stable-isotope reductive dimethylation, a cost-effective, simple, robust, reliable and easy-to-
multiplex labelling method, is widely applied to quantitative proteomics using liquid …

The cell membrane plays an important role in protecting the cell from its extracellular
environment. As such, extensive work has been devoted to studying its structure and …