How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

[HTML][HTML] AI-based monitoring of retinal fluid in disease activity and under therapy

U Schmidt-Erfurth, GS Reiter, S Riedl… - Progress in retinal and …, 2022 - Elsevier
Retinal fluid as the major biomarker in exudative macular disease is accurately visualized by
high-resolution three-dimensional optical coherence tomography (OCT), which is used …

Multimodal imaging in diabetic retinopathy and macular edema: An update about biomarkers

M Parravano, G Cennamo, L Di Antonio… - Survey of …, 2024 - Elsevier
Diabetic macular edema (DME), defined as retinal thickening near, or involving the fovea
caused by fluid accumulation in the retina, can lead to vision impairment and blindness in …

Deep learning models for screening of high myopia using optical coherence tomography

KJ Choi, JE Choi, HC Roh, JS Eun, JM Kim, YK Shin… - Scientific reports, 2021 - nature.com
This study aimed to validate and evaluate deep learning (DL) models for screening of high
myopia using spectral-domain optical coherence tomography (OCT). This retrospective …

Clinical validation of saliency maps for understanding deep neural networks in ophthalmology

MS Ayhan, LB Kümmerle, L Kühlewein, W Inhoffen… - Medical Image …, 2022 - Elsevier
Deep neural networks (DNNs) have achieved physician-level accuracy on many imaging-
based medical diagnostic tasks, for example classification of retinal images in …

Validation of an automated artificial intelligence algorithm for the quantification of major OCT parameters in diabetic macular edema

E Midena, L Toto, L Frizziero, G Covello… - Journal of clinical …, 2023 - mdpi.com
Artificial intelligence (AI) and deep learning (DL)-based systems have gained wide interest
in macular disorders, including diabetic macular edema (DME). This paper aims to validate …

Attention-based multi-scale feature fusion network for myopia grading using optical coherence tomography images

G Huang, Y Wen, B Qian, L Bi, T Chen, B Sheng - The Visual Computer, 2024 - Springer
Myopia is a serious threat to eye health and can even cause blindness. It is important to
grade myopia and carry out targeted intervention. Nowadays, various studies using deep …

Therapeutic response in the HAWK and HARRIER trials using deep learning in retinal fluid volume and compartment analysis

U Schmidt-Erfurth, Z Mulyukov, BS Gerendas… - Eye, 2023 - nature.com
Objectives To assess the therapeutic response to brolucizumab and aflibercept by deep
learning/OCT-based analysis of macular fluid volumes in neovascular age-related macular …

Predicting treat-and-extend outcomes and treatment intervals in neovascular age-related macular degeneration from retinal optical coherence tomography using …

H Bogunović, V Mares, GS Reiter… - Frontiers in …, 2022 - frontiersin.org
Purpose To predict visual outcomes and treatment needs in a treat & extend (T&E) regimen
in neovascular age-related macular degeneration (nAMD) using a machine learning model …

The role of medical image modalities and AI in the early detection, diagnosis and grading of retinal diseases: a survey

GA Saleh, NM Batouty, S Haggag, A Elnakib, F Khalifa… - Bioengineering, 2022 - mdpi.com
Traditional dilated ophthalmoscopy can reveal diseases, such as age-related macular
degeneration (AMD), diabetic retinopathy (DR), diabetic macular edema (DME), retinal tear …