The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …

Individual cells within an otherwise genetically homogenous population constantly undergo
fluctuations in their molecular state, giving rise to non-genetic heterogeneity. Such diversity …

Background Many biological processes, such as cell division cycle and drug resistance, are
reflected in protein covariation across single cells. This covariation can be quantified and …

In metastasis, cancer cells travel around the circulation to colonize distant sites. Due to the
rarity of these events, the immediate fates of metastasizing tumor cells (mTCs) are poorly …

RNA labeling in situ has enormous potential to visualize transcripts and quantify their levels
in single cells, but it remains challenging to produce high levels of signal while also …

Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …

Gene expression states persist for varying lengths of time at the single-cell level, a
phenomenon known as gene expression memory. When cells switch states, losing memory …

The era of genomic medicine has allowed acute myeloid leukemia (AML) researchers to
improve disease characterization, optimize risk-stratification systems, and develop new …