The reaction takes place at a specialized metal center that dramatically increases the acidity
of H2 and leads to a heterolytic splitting of the molecule which is strongly accelerated by the …

Redox reactions play important roles in almost all biological processes, including
photosynthesis and respiration, which are two essential energy processes that sustain all life …

It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Noyori-type catalysts have found numerous applications in research and industrial settings.
The central mechanistic component of such catalysts is a metal centre coordinated to a N–H …

Abstract The [FeFe]-and [NiFe]-hydrogenases catalyze the formal interconversion between
hydrogen and protons and electrons, possess characteristic non-protein ligands at their …

Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food
industries, in addition to being a daily consideration for academic researchers studying …

The mechanism of nitrogenase remains enigmatic, with a major unresolved issue
concerning how inhibitors and substrates bind to the active site. We report a crystal structure …

Over the last 15 years, a plethora of research has provided major insights into the structure
and function of hydrogenase enzymes. This has led to the important development of …

Most amino acids are encoded by multiple codons, and codon choice has strong effects on
protein expression. Rare codons are enriched at the N terminus of genes in most organisms …

Hydrogenases catalyze the formation of hydrogen. The cofactor ('H-cluster') of [FeFe]-
hydrogenases consists of a [4Fe-4S] cluster bridged to a unique [2Fe] subcluster whose …