Mechanistic understanding from molecular dynamics simulation in pharmaceutical research 1: drug delivery

A Bunker, T Róg - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
In this review, we outline the growing role that molecular dynamics simulation is able to play
as a design tool in drug delivery. We cover both the pharmaceutical and computational …

Theoretical assessments on the interaction between amino acids and the g-Mg 3 N 2 monolayer: dispersion corrected DFT and DFT-MD simulations

M Rezvani, M Astaraki, A Rahmanzadeh… - Physical Chemistry …, 2021 - pubs.rsc.org
The interaction of a few amino acids (AAs) with the graphene-like magnesium nitride (g-
Mg3N2) monolayer has been investigated with density functional theory (DFT) simulations …

Assessment of the adsorption mechanism of Flutamide anticancer drug on the functionalized single-walled carbon nanotube surface as a drug delivery vehicle: An …

M Kamel, H Raissi, A Morsali, M Shahabi - Applied Surface Science, 2018 - Elsevier
In the present work, we have studied the drug delivery performance of the functionalized (5,
5) single-walled carbon nanotube with a carboxylic acid group for Flutamide anticancer drug …

A combined theoretical and experimental study to improve the thermal stability of recombinant D‐lactate dehydrogenase immobilized on a novel superparamagnetic …

M Torkzadeh‐Mahani, M Zaboli… - Applied …, 2020 - Wiley Online Library
Lactate dehydrogenase (LDH) is an enzyme that catalyzes the reduction of nicotinamide
adenine dinucleotide (NADH) and pyruvate to nicotinamide adenine dinucleotide (NAD+) …

DFT and MD investigations on the functionalized boron nitride nanotube as an effective drug delivery carrier for Carmustine anticancer drug

A Mortazavifar, H Raissi, A Akbari - Journal of Molecular Liquids, 2019 - Elsevier
In the present work, we apply density functional theory (DFT) calculations to investigate the
drug delivery performance of the boron nitride nanotube (BNNT) having hydroxyl functional …

The functionalization of carbon nanotubes to enhance the efficacy of the anticancer drug paclitaxel: a molecular dynamics simulation study

H Hashemzadeh, H Raissi - Journal of Molecular Modeling, 2017 - Springer
Carbon nanotubes (CNTs) are widely used in drug delivery systems (DDSs) due to their
unique chemical and physical properties. Investigation of interactions between biomolecules …

The effect of different percentages of triethanolammonium butyrate ionic liquid on the structure and activity of urate oxidase: Molecular docking, molecular dynamics …

S Ghanbari-Ardestani, S Khojasteh-Band… - Journal of Molecular …, 2019 - Elsevier
Ionic liquids (ILs) are a class of salts with low melting points that can change the structure,
function, and stability of proteins. Numerous researches have been focused on finding the …

Investigation of the solvent effect, molecular structure, electronic properties and adsorption mechanism of Tegafur anticancer drug on Graphene nanosheet surface as …

M Shahabi, H Raissi - Journal of Inclusion Phenomena and Macrocyclic …, 2017 - Springer
To understanding the adsorption mechanism and the induced effects of an anticancer drug,
Tegafur molecule, on the surface of Graphene nanosheet (GNS) as a drug delivery system …

Predicting doxorubicin drug delivery by single-walled carbon nanotube through cell membrane in the absence and presence of nicotine molecules: a molecular …

M Pakdel, H Raissi, M Shahabi - Journal of Biomolecular Structure …, 2020 - Taylor & Francis
In order to study the interaction of the anticancer agent Doxorubicin with the single-walled
carbon nanotubes with different diameters as drug delivery systems, the molecular dynamics …

Investigation of nanotubes as the smart carriers for targeted delivery of mercaptopurine anticancer drug

M Zaboli, H Raissi, M Zaboli - Journal of Biomolecular Structure …, 2022 - Taylor & Francis
Mercaptopurine (MCP) is an anticancer drug that is used to treat acute lymphoblastic
leukemia. The therapeutic effect of the mercaptopurine limits its severe side effects like other …