Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

[HTML][HTML] Neutrophil: a cell with many roles in inflammation or several cell types?

C Rosales - Frontiers in physiology, 2018 - frontiersin.org
Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as
first line of defense in the innate arm of the immune system. They capture and destroy …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

F Di Virgilio, AC Sarti, S Falzoni, E De Marchi… - Nature Reviews …, 2018 - nature.com
Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

Cancer nanotechnology: current status and perspectives

JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Consensus guidelines for the detection of immunogenic cell death

O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Icaritin exacerbates mitophagy and synergizes with doxorubicin to induce immunogenic cell death in hepatocellular carcinoma

Z Yu, J Guo, M Hu, Y Gao, L Huang - Acs Nano, 2020 - ACS Publications
Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is
among the deadliest malignancies. Doxorubicin widely used in transarterial chemotherapy …

Contribution of angiogenesis to inflammation and cancer

D Aguilar-Cazares, R Chavez-Dominguez… - Frontiers in …, 2019 - frontiersin.org
During carcinogenesis, advanced tumors are surrounded by both stromal and immune cells,
which support tumor development. In addition, inflammation and angiogenesis are …

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

H Deng, W Yang, Z Zhou, R Tian, L Lin, Y Ma… - Nature …, 2020 - nature.com
Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened
by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of …

Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses

AD Garg, P Agostinis - Immunological reviews, 2017 - Wiley Online Library
The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond develo** immunostimulatory regimens like dendritic cell‐based …