The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin
remains controversial. ROR is inextricably linked to melatonin in terms of its expression …

Introduction: The transcription factor retinoic acid-related orphan receptor gamma t (RORγt)
has been identified as the master regulator of TH17 cell differentiation and IL-17/22 …

Trained immunity is a long-lasting change in the responsiveness of innate immune cells,
leading to a stronger response upon an unrelated secondary challenge. Epigenetic …

Bisphenol A (BPA) has deleterious effects on bone metabolism; however, its underlying
mechanism has not yet been comprehensively understood. Here, we investigated whether …

Aberrant cholesterol metabolism and homeostasis in the form of elevated cholesterol
biosynthesis and dysregulated efflux and metabolism is well recognized as a major feature …

Ischemic stroke is highly concerning because it often leads to severe long-term neurological
disability. Among clinical trials, ischemic stroke and inflammatory bowel disease interactions …

Simple Summary Cancer is a major public health problem worldwide and one of the major
causes of mortality. Current therapies are becoming ineffective due to intratumoral …

Vitamin A is essential for brain function, in addition to its important roles in vision, immunity,
and reproduction. Previous studies have shown that retinoic acid (RA), the bioactive form of …

The Earth's 24-h planetary rotation, with predictable light and heat cycles, has driven
profound evolutionary adaptation, with prominent impacts on physiological mechanisms …