Airflow and particle transport in the human respiratory system

C Kleinstreuer, Z Zhang - Annual review of fluid mechanics, 2010 - annualreviews.org
Airflows in the nasal cavities and oral airways are rather complex, possibly featuring a
transition to turbulent jet-like flow, recirculating flow, Dean's flow, vortical flows, large …

Deposition of inhaled particles in the lungs

AF Tena, PC Clarà - Archivos de Bronconeumología (English Edition), 2012 - Elsevier
Inhaled medication is the first-line treatment of diseases such as asthma or chronic
obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited …

Flow structure and particle deposition analyses for optimization of a pressurized metered dose inhaler (pMDI) in a model of tracheobronchial airway

K Ahookhosh, M Saidi, M Mohammadpourfard… - European Journal of …, 2021 - Elsevier
Inhalation therapy plays an important role in management or treatment of respiratory
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …

Modeling airflow and particle transport/deposition in pulmonary airways

C Kleinstreuer, Z Zhang, Z Li - Respiratory physiology & neurobiology, 2008 - Elsevier
A review of research papers is presented, pertinent to computer modeling of airflow as well
as nano-and micron-size particle deposition in pulmonary airway replicas. The key modeling …

On intra-and intersubject variabilities of airflow in the human lungs

J Choi, MH Tawhai, EA Hoffman, CL Lin - Physics of Fluids, 2009 - pubs.aip.org
The effects of intra-and intersubject variabilities in airway geometry on airflow in the human
lungs are investigated by large eddy simulation. The airway models of two human subjects …

Fabrication of rigid and flexible refractive-index-matched flow phantoms for flow visualisation and optical flow measurements

PH Geoghegan, NA Buchmann, CJT Spence… - Experiments in …, 2012 - Springer
A method for the construction of both rigid and compliant (flexible) transparent flow
phantoms of biological flow structures, suitable for PIV and other optical flow methods with …

Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data

K Ahookhosh, M Saidi, H Aminfar… - International journal of …, 2020 - Elsevier
Effective drug delivery into the lungs plays an important role in management of pulmonary
diseases that affect millions all around the world. The main objective of this investigation is …

Numerical study of high-frequency oscillatory air flow and convective mixing in a CT-based human airway model

J Choi, G **a, MH Tawhai, EA Hoffman… - Annals of biomedical …, 2010 - Springer
High-frequency oscillatory ventilation (HFOV) is considered an efficient and safe respiratory
technique to ventilate neonates and patients with acute respiratory distress syndrome. HFOV …

Development of a realistic human airway model

F Lizal, J Elcner, PK Hopke… - Proceedings of the …, 2012 - journals.sagepub.com
Numerous models of human lungs with various levels of idealization have been reported in
the literature; consequently, results acquired using these models are difficult to compare to …

Experimental methods for flow and aerosol measurements in human airways and their replicas

F Lizal, J Jedelsky, K Morgan, K Bauer, J Llop… - European Journal of …, 2018 - Elsevier
Recent developments in the prediction of local aerosol deposition in human lungs are driven
by the fast development of computational simulations. Although such simulations provide …