Bacterial battle against acidity
J Schwarz, K Schumacher, S Brameyer… - FEMS Microbiology …, 2022 - academic.oup.com
The Earth is home to environments characterized by low pH, including the gastrointestinal
tract of vertebrates and large areas of acidic soil. Most bacteria are neutralophiles, but can …
tract of vertebrates and large areas of acidic soil. Most bacteria are neutralophiles, but can …
The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications
J Kahlhofer, D Teis - Basic & Clinical Pharmacology & …, 2023 - Wiley Online Library
LAT1 and 4F2hc form a heterodimeric membrane protein complex, which functions as one of
the best characterized amino acid transporters. Since LAT1–4F2hc is required for the …
the best characterized amino acid transporters. Since LAT1–4F2hc is required for the …
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …
Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
R Yan, Y Li, J Müller, Y Zhang, S Singer, L **a… - Cell discovery, 2021 - nature.com
Abstract LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric
amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc …
amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc …
Reevaluating the substrate specificity of the L-type amino acid transporter (LAT1)
The L-type amino acid transporter 1 (LAT1, SLC7A5) transports essential amino acids
across the blood–brain barrier (BBB) and into cancer cells. To utilize LAT1 for drug delivery …
across the blood–brain barrier (BBB) and into cancer cells. To utilize LAT1 for drug delivery …
Natural products derived from medicinal plants and microbes might act as a game-changer in breast cancer: A comprehensive review of preclinical and clinical studies
Breast cancer (BC) is the most prevalent neoplasm among women. Genetic and
environmental factors lead to BC development and on this basis, several preventive …
environmental factors lead to BC development and on this basis, several preventive …
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
E Errasti-Murugarren, J Fort, P Bartoccioni… - Nature …, 2019 - nature.com
L-amino acid transporters (LATs) play key roles in human physiology and are implicated in
several human pathologies. LATs are asymmetric amino acid exchangers where the low …
several human pathologies. LATs are asymmetric amino acid exchangers where the low …
High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding
Background The L-arginine/agmatine transporter AdiC is part of the arginine-dependent
extreme acid resistance system of the bacterium Escherichia coli and its pathogenic …
extreme acid resistance system of the bacterium Escherichia coli and its pathogenic …
Arginine transportation mechanism through cationic amino acid transporter 1: insights from molecular dynamics studies
Metabolic and signaling mechanisms in mammalian cells are facilitated by the transportation
of L-arginine (Arg) across the plasma membrane through cationic amino acid transporter …
of L-arginine (Arg) across the plasma membrane through cationic amino acid transporter …
Function and regulation of acid resistance antiporters
EM Krammer, M Prévost - The Journal of Membrane Biology, 2019 - Springer
Bacterial pathogens are a major cause of foodborne diseases and food poisoning. To cope
with the acid conditions encountered in different environments such as in fermented food or …
with the acid conditions encountered in different environments such as in fermented food or …