Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often
preceded by insulin resistance (IR), which underlies the inability of tissues to respond to …

As a novel type of non-coding RNAs, covalently closed circular RNAs (circRNAs) are
ubiquitously expressed in eukaryotes. Emerging studies have indicated that dysregulation of …

Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding
and predicting disease development. To what extent this reflects a primary defect or is …

Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling
pathways but have unique biological effects. To define the molecular signals contributing to …

Insulin resistance is present in one-quarter of the general population, predisposing these
people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of …

Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew
and drive tumorigenicity could identify new treatments. Through comparative chromatin-state …

Insulin acts through the insulin receptor (IR) tyrosine kinase to exert its classical metabolic
and mitogenic actions. Here, using receptors with either short or long deletion of the β …

Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disorder caused by
overnutrition and can lead to nonalcoholic steatohepatitis (NASH) and hepatocellular …

Abstract Background Forkhead box C1 (FOXC1), as a member of the FOX family, is
important for promote HCC invasion and metastasis. FOX family protein lays a pivotal role in …