Pharmacogenetics guidelines: overview and comparison of the DPWG, CPIC, CPNDS, and RNPGx guidelines
H Abdullah-Koolmees, AM Van Keulen… - Frontiers in …, 2021 - frontiersin.org
Many studies have shown that the efficacy and risk of side effects of drug treatment is
influenced by genetic variants. Evidence based guidelines are essential for implementing …
influenced by genetic variants. Evidence based guidelines are essential for implementing …
The clinical pharmacogenetics implementation consortium: 10 years later
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www. cpicpgx.
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …
The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data
Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …
[HTML][HTML] A case study on decentralized manufacturing of 3D printed medicines
Abstract Pharmaceutical 3D printing (3DP) is one of the emerging enabling technologies of
personalised medicines as it affords the ability to fabricate highly versatile dosage forms. In …
personalised medicines as it affords the ability to fabricate highly versatile dosage forms. In …
CYP2B6 functional variability in drug metabolism and exposure across populations—implication for drug safety, dosing, and individualized therapy
IM Langmia, KS Just, S Yamoune, J Brockmöller… - Frontiers in …, 2021 - frontiersin.org
Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …
Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank
Pharmacogenomics (PGx) is an integral part of precision medicine and contributes to the
maximization of drug efficacy and reduction of adverse drug event risk. Accurate information …
maximization of drug efficacy and reduction of adverse drug event risk. Accurate information …
PharmVar GeneFocus: CYP2B6
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature
for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus …
for the polymorphic human CYP2B6 gene. Genetic variation within the CYP2B6 gene locus …
Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs
OA Badary - The pharmacogenomics journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …
Clinically important alterations in pharmacogene expression in histologically severe nonalcoholic fatty liver disease
Polypharmacy is common in patients with nonalcoholic fatty liver disease (NAFLD) and
previous reports suggest that NAFLD is associated with altered drug disposition. This study …
previous reports suggest that NAFLD is associated with altered drug disposition. This study …
A population study of clinically actionable genetic variation affecting drug response from the Middle East
Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions
and alleviate the personal and financial burden due to inefficacy and adverse reactions to …
and alleviate the personal and financial burden due to inefficacy and adverse reactions to …