Obesity: a gender-view

G Muscogiuri, L Verde, C Vetrani, L Barrea… - Journal of …, 2024 - Springer
Purpose There is a growing awareness of the importance of understanding gender
differences in obesity. The aim of this short review was to revise the current evidence on …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N **e, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

[HTML][HTML] Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice

J Liu, J Shi, R Hernandez, X Li, P Konchadi… - Environment …, 2023 - Elsevier
Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is
associated with the increased risk of many chronic diseases. For example, phthalate …

Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions

SR Bernstein, C Kelleher, RA Khalil - Biochemical pharmacology, 2023 - Elsevier
Earlier research has presumed that the male and female biology is similar in most organs
except the reproductive system, leading to major misconceptions in research interpretations …

Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy

CR Clark, RA Khalil - Biochemical Pharmacology, 2024 - Elsevier
Abstract Normal pregnancy (Norm-Preg) is associated with a slight reduction in blood
pressure (BP) and decreased BP response to vasoconstrictor stimuli such as angiotensin II …

[HTML][HTML] The sexual dimorphism of human adipose depots

N Boulet, A Briot, J Galitzky, A Bouloumié - Biomedicines, 2022 - mdpi.com
The amount and the distribution of body fat exhibit trajectories that are sex-and human
species-specific and both are determinants for health. The enhanced accumulation of fat in …

Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring's health phenotypes in a mouse model

E Chen, RS da Cruz, A Nascimento, M Joshi… - Scientific Reports, 2024 - nature.com
Mounting evidence suggests that environmentally induced epigenetic inheritance occurs in
mammals and that traits in the progeny can be shaped by parental environmental …

[HTML][HTML] Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury

LC Pantaleão, E Loche, DS Fernandez-Twinn… - Molecular …, 2024 - Elsevier
Objective We investigated the potential involvement of miRNAs in the developmental
programming of cardiovascular diseases (CVD) by maternal obesity. Methods Serum …

Exposure to polystyrene microplastics during lactational period alters immune status in both male mice and their offspring

Q Shang, H Wu, K Wang, M Zhang, Y Dou… - Science of The Total …, 2024 - Elsevier
The widespread use of microplastics and their harmful effects on the environment have
emerged as serious concerns. However, the effect of microplastics on the immune system of …

Maternal high fat diet in lactation impacts hypothalamic neurogenesis and neurotrophic development, leading to later life susceptibility to obesity in male but not …

Y Xu, D Yang, L Wang, E Król, M Mazidi, L Li… - Advanced …, 2023 - Wiley Online Library
Early life nutrition can reprogram development and exert long‐term consequences on body
weight regulation. In mice, maternal high‐fat diet (HFD) during lactation predisposed male …