Activatable nano-photosensitizers for precise photodynamic cancer therapy

Z Li, Z Zhou, Y Wang, J Wang, L Zhou… - Coordination Chemistry …, 2023 - Elsevier
Owing to the excellent cell ablation ability and low side effects, photodynamic therapy (PDT)
plays an important role in disease treatment, especially cancer. However, most PDT agents …

Tumor microenvironment-based stimuli-responsive nanoparticles for controlled release of drugs in cancer therapy

W Zhou, Y Jia, Y Liu, Y Chen, P Zhao - Pharmaceutics, 2022 - mdpi.com
With the development of nanomedicine technology, stimuli-responsive nanocarriers play an
increasingly important role in antitumor therapy. Compared with the normal physiological …

An AIE photosensitizer with simultaneous type I and type II ROS generation: efficient bacterial elimination and hypoxic tumor ablation

Y Wang, J Liao, Y Lyu, Q Guo, Z Zhu… - Advanced Functional …, 2023 - Wiley Online Library
Aggregation induced emission (AIE) photosensitizers have attracted great attention due to
their good performance in photodynamic therapy (PDT). However, the therapeutic effect of …

[HTML][HTML] Nanomedicine: Technologies and Applications

M Farrokhi, F Taheri, M Farrokhi, YEK Tosi… - Kindle, 2024 - preferpub.org
Nanomedicine is an innovative field that merges nanotechnology with medicine, aiming to
enhance diagnosis, treatment, and prevention of diseases at the molecular level. This …

Camptothecin-based prodrug nanomedicines for cancer therapy

R Zhang, J Yu, Z Guo, H Jiang, C Wang - Nanoscale, 2023 - pubs.rsc.org
Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via
blocking DNA topoisomerase 1. Despite its encouraging and wide-spectrum antitumour …

Covalent organic framework nanoparticles: Overcoming the challenges of hypoxia in cancer therapy

N Singh, M Won, Y Xu, C Yoon, J Yoo, M Li… - Coordination Chemistry …, 2024 - Elsevier
Hypoxia, or low oxygen levels, is a common feature of the tumor microenvironment. It is
caused by the aggressive proliferation of cancer cells, which consume more oxygen than …

Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatment

J Huang, Y Zhu, H **ao, J Liu, S Li, Q Zheng, J Tang… - Chinese Medicine, 2023 - Springer
Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a
variety of illnesses, and its popularity is increasing worldwide. However, the clinical …

Dual-driven nanomotors enable tumor penetration and hypoxia alleviation for calcium overload-photo-immunotherapy against colorectal cancer

J Wu, S Yi, Y Cao, M Zu, B Li, W Yang, MA Shahbazi… - Biomaterials, 2023 - Elsevier
The treatment efficacies of conventional medications against colorectal cancer (CRC) are
restricted by a low penetrative, hypoxic, and immunosuppressive tumor microenvironment …

Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy

X Zheng, Q Zhang, X Wang, J Chen, J Wu… - Chemical …, 2024 - pubs.rsc.org
Nanoscale metal–organic frameworks integrated with porphyrins (Por-nMOFs) have
emerged as efficient nanoplatforms for photodynamic therapy (PDT), which relies on the …

Effective drug and shRNA delivery for synergistic treatment of triple-negative breast cancer by sequentially targeting tumor hypoxia

X Liu, J Sun, J Gu, L Weng, X Wang, L Zhu… - Chemical Engineering …, 2023 - Elsevier
Clinical treatment of TNBC remains challenging, due to the lack of targeted therapies. As
TNBC is highly hypoxic with higher HIF-1α expression than other subtypes, we fabricated …