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Pancreatic ductal adenocarcinoma and its variants: pearls and perils
Pancreatic ductal adenocarcinoma (PDAC), an epithelial neoplasm derived from the
pancreatic ductal tree, is the most common histologic type of pancreatic cancer and …
pancreatic ductal tree, is the most common histologic type of pancreatic cancer and …
Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review
Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of
the pancreas, overall survival is poor. Characteristics of ASCP include central tumor …
the pancreas, overall survival is poor. Characteristics of ASCP include central tumor …
A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma
Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The
extent to which these profiles vary within a patient is unknown. We integrated evolutionary …
extent to which these profiles vary within a patient is unknown. We integrated evolutionary …
Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma
H Tamagawa, M Fujii, K Togasaki, T Seino… - Nature Cell …, 2024 - nature.com
Human pancreatic cancer is characterized by the molecular diversity encompassing native
duct-like and squamous cell-like identities, but mechanisms underlying squamous …
duct-like and squamous cell-like identities, but mechanisms underlying squamous …
Morphologic and molecular landscape of pancreatic cancer variants as the basis of new therapeutic strategies for precision oncology
To date, pancreatic cancer is still one of the most lethal cancers in the world, mainly due to
the lack of early diagnosis and personalized treatment strategies. In this context, the …
the lack of early diagnosis and personalized treatment strategies. In this context, the …
Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia
RDW Vaes, DPJ van Dijk, TTJ Welbers… - Journal of cachexia …, 2020 - Wiley Online Library
Background The majority of patients with pancreatic cancer develops cachexia. The
mechanisms underlying cancer cachexia development and progression remain elusive …
mechanisms underlying cancer cachexia development and progression remain elusive …
A phase II trial of the super-enhancer inhibitor Minnelide™ in advanced refractory adenosquamous carcinoma of the pancreas
Adenosquamous carcinoma of the pancreas (ASCP) is a very rare and highly aggressive
variant of pancreatic ductal adenocarcinoma, accounting for 0.5–4% of all pancreatic cancer …
variant of pancreatic ductal adenocarcinoma, accounting for 0.5–4% of all pancreatic cancer …
Genomic signatures of pancreatic adenosquamous carcinoma (PASC)
In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal
adenocarcinoma and squamous carcinoma in the same tumour represents∼ 4% of the total …
adenocarcinoma and squamous carcinoma in the same tumour represents∼ 4% of the total …
Epidemiology of adenosquamous carcinomas
Background Adenosquamous carcinomas (ASCs) are a very rare histology containing
cancer cells with both glandular-like (adeno) and squamous cell histologies, comprising …
cancer cells with both glandular-like (adeno) and squamous cell histologies, comprising …
Systemic chemotherapy for advanced rare pancreatic histotype tumors: a retrospective multicenter analysis
Objectives Two issues were put forth by clinicians in the management of the advanced
stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes …
stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes …