Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

Copper is a critical trace element in biological systems due the vast number of essential
enzymes that require the metal as a cofactor, including cytochrome c oxidase, superoxide …

Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids,
including homocysteine and exerts neuroprotective effects. An increase of homocysteine …

The antioxidant properties of melatonin can be successfully used to reduce the effects of
oxidative stress caused by homocysteine. The beneficial actions of melatonin are mainly …

Although the tricyclic antidepressant amitriptyline (ATL) is widely used in the clinic, the
mechanism underlying its high therapeutic efficacy against neuropathic pain remains …

Purpose To investigate the associations among homocysteine (Hcy), inflammation and
cognitive impairment in patients with acute ischemic stroke (AIS) and transient ischemic …

According to modern view, susceptibility to diseases, specifically to cognitive and
neuropsychiatric disorders, can form during embryonic development. Adverse factors …

Introduction: Although drugs currently available for the treatment of anxiety and depression
act through modulation of the neurotransmission systems involved in the neurobiology of the …

Several lines of evidence suggest that the aggregation and deposition of amyloid‐β peptide
(Aβ) initiate the pathology of Alzheimer's disease (AD). Recently, a genome‐wide …

Hyperhomocysteinemia (hHCY) is a metabolic disorder characterized by elevated levels of
homocysteine in plasma. hHCY correlates with a high risk of migraine headaches …