Allogeneic haematopoietic stem-cell transplantation (HSCT) is frequently applied as part of
the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent …

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of
growth factor-induced T cell proliferation. However, it is now evident that the …

Hepatic sinusoidal obstruction syndrome (SOS) is an obliterative venulitis of the terminal
hepatic venules, which in its more severe forms imparts a high risk of mortality. SOS, also …

Because of its potent immunosuppressive yet stem cell–sparing activity, high-dose
cyclophosphamide was tested as sole prophylaxis of graft-versus-host disease (GVHD) after …

Background Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in
children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection …

Approximately one-third of patients with an indication for hematopoietic cell transplantation
(HCT) have an HLA-matched related donor (MRD) available to them. For the remaining …

Abstract Grades 2-4 acute graft-versus-host disease (GVHD) occurs in approximately 35% of
matched, related donor (MRD) allogeneic hematopoietic cell transplantation (HCT) …

Complications of allogeneic hematopoietic stem cell transplantation (HSCT) remain barriers
to its wider application for a variety of diseases. Graft-versus-host disease (GVHD) is the …

Previous randomized graft-versus-host disease (GVHD)-prophylaxis trials have failed to
demonstrate reduced incidence and severity of chronic GVHD (cGVHD). Here we …

Graft-versus-host disease, or GVHD, is a major complication of allogeneic hematopoietic
stem cell transplantation (alloHSCT) for the treatment of hematologic malignancies. Here …