Abstract Haloalkane dehalogenases (EC 3.8. 1.5, HLDs) are α/β‐hydrolases which act to
cleave carbon‐halogen bonds. Due to their unique catalytic mechanism, broad substrate …

Neutron crystallography has had an important, but relatively small role in structural biology
over the years. In this review of recently determined neutron structures, a theme emerges of …

Industrialism has brought a long series of benefits for modern civilization. Concomitantly,
reversible and irreversible changes have been inflicted upon the environment, affecting …

Roughly one-third of all proteins reside in biological membranes [1, 2]. Integral membrane
proteins (IMPs), which can only be released from the membrane by disruption of the …

At the Institut Laue–Langevin, a new neutron Laue diffractometer LADI-III has been fully
operational since March 2007. LADI-III is dedicated to neutron macromolecular …

Neutron crystallography allows direct determination of the proton and deuteron positions of
a macromolecule and its bound solvent. Key advances in neutron macromolecular …

Many polyketide natural products exhibit invaluable medicinal properties, yet much remains
to be understood regarding the machinery responsible for their biosynthesis. The recently …

In vivo generated deuterated bacterial cellulose, cultivated from 100% deuterated glycerol in
D2O medium, was analyzed for deuterium incorporation by ionic liquid dissolution and 2H …

Identifying the viability of protein targets is one of the preliminary steps of drug discovery.
Determining the ability of a protein to bind drugs in order to modulate its function, termed the …

Scaffolding proteins are molecular switches that control diverse signaling events. The
scaffolding protein Na+/H+ exchanger regulatory factor 1 (NHERF1) assembles …