Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a
primary site of nephrotoxicity and resulting attrition in the drug development pipeline …

Tubulointerstitial fibrosis and glomerulosclerosis, are a major feature of end stage chronic
kidney disease (CKD), characterised by an excessive accumulation of extracellular matrix …

Kidney transplantation is one of the most common transplantation operations in the world,
accounting for up to 50% of all transplantation surgeries. To curtail the damage to …

Background Common genetic variants of the enzymes and efflux pump involved in
tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but …

Background Kidney injury molecule-1 (KIM-1) is expressed in tubular epithelial cells after
injury and may have a role in the development of renal graft fibrosis. In this study we …

Background. Inflammation within areas of interstitial fibrosis and tubular atrophy (IF/TA) is
associated with kidney allograft failure. The aim of this study was to reveal new diagnostic …

Histological evaluations of renal allograft biopsies are essential for diagnosis, but still show
a low predictive value for long‐term allograft function. One limitation relies on the fact that …

Background Epidemiological studies have investigated the role of transforming growth factor-
β1 (TGF-β1) in chronic allograft dysfunction (CAD) following kidney transplantation. TGFB1 …

Background Unexplained graft fibrosis and inflammation are common after pediatric liver
transplantation (LT). Objective We investigated the graft expression of fibrogenic genes and …

Abstract Background Mesenchymal stem cells (MSCs)-based therapy has shown promising
results for renal injury. In this study, the efficacy and safety of autologous bone marrow …