Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Rationale: Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) are
increasingly being used for modeling heart disease and are under development for …

Background Whereas heart failure with reduced ejection fraction (HFrEF) is associated with
ventricular dilation and markedly reduced systolic function, heart failure with preserved …

Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic
characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over …

Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where
invaginations of the surface membrane (t-tubules) form functional junctions with the …

Heart failure (HF) is a complication of multiple cardiac diseases and is characterized by
impaired contractile and electric function. Patients with HF are not only limited by reduced …

Ion channels and cytoskeletal proteins in the cardiac dyad play a critical role in maintaining
excitation-contraction (EC) coupling and provide cardiac homeostasis. Functional changes …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …

Mechanical load is a potent regulator of cardiac structure and function. Although high
workload during heart failure is associated with disruption of cardiomyocyte t‐tubules and …