Cationic polymers have recently attracted considerable interest as research breakthroughs
for various industrial and biomedical applications. They are particularly interesting due to …

Gene therapy has attracted much attention because of its unique mechanism of action, non-
toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues …

Double pH-responsive xenopeptide carriers containing succinoyl tetraethylene pentamine
(Stp) and lipo amino fatty acids (LAFs) were evaluated for CRISPR/Cas9 based genome …

Hypoxia and low glucose abundance often occur simultaneously at sites of inflammation. In
monocytes and macrophages, glucose-oxygen deprivation stimulates the assembly of the …

An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide
delivery into the lung is presented in this review, with a special focus on lung cancer. Due to …

Despite the impressive strides in the research community, numerous obstacles pose marked
challenges in the treatment of central nervous system (CNS) disorders. The limitations of …

Nucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors
thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous …

Spray-drying of nucleic acid-based drugs designed for gene therapy or gene knockdown is
associated with many advantages including storage stability and handling as well as the …

Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-
to-date results obtained from in vitro experiments predict the in vivo performance of …

Kaposi's sarcoma-associated herpesvirus (KSHV) infection can cause a range of
malignancies. The use of microRNA (miRNA) to combat viruses and inhibit tumor …