High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
The sweet spot: defining virus–sialic acid interactions
JE Stencel-Baerenwald, K Reiss, DM Reiter… - Nature Reviews …, 2014 - nature.com
Viral infections are initiated by attachment of the virus to host cell surface receptors,
including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan …
including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan …
A useful guide to lectin binding: machine-learning directed annotation of 57 unique lectin specificities
Glycans are critical to every facet of biology and medicine, from viral infections to
embryogenesis. Tools to study glycans are rapidly evolving; however, the majority of our …
embryogenesis. Tools to study glycans are rapidly evolving; however, the majority of our …
Probing the binding specificities of human Siglecs by cell-based glycan arrays
C Büll, R Nason, L Sun, J Van Coillie… - Proceedings of the …, 2021 - National Acad Sciences
Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune
system and a few other cell types capable of modulating immune cell functions upon …
system and a few other cell types capable of modulating immune cell functions upon …
An atlas of human glycosylation pathways enables display of the human glycome by gene engineered cells
The structural diversity of glycans on cells—the glycome—is vast and complex to decipher.
Glycan arrays display oligosaccharides and are used to report glycan hapten binding …
Glycan arrays display oligosaccharides and are used to report glycan hapten binding …
Involvement of a non-human sialic acid in human cancer
Sialic acids are common monosaccharides that are widely expressed as outer terminal units
on all vertebrate cell surfaces, and play fundamental roles in cell–cell and cell …
on all vertebrate cell surfaces, and play fundamental roles in cell–cell and cell …
The interaction of the gut microbiota with the mucus barrier in health and disease in human
AP Corfield - Microorganisms, 2018 - mdpi.com
Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and
other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for …
other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for …
Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms
K Kawanishi, C Dhar, R Do, N Varki… - Proceedings of the …, 2019 - National Acad Sciences
Cardiovascular disease (CVD) events due to atherosclerosis cause one-third of worldwide
deaths and risk factors include physical inactivity, age, dyslipidemia, hypertension, diabetes …
deaths and risk factors include physical inactivity, age, dyslipidemia, hypertension, diabetes …
[HTML][HTML] Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc
L Parhi, J Abed, A Shhadeh, T Alon-Maimon, S Udi… - Cell Reports, 2022 - cell.com
While the existence of an indigenous placental microbiota remains controversial, several
pathogens are known to be involved in adverse pregnancy outcomes. Fusobacterium …
pathogens are known to be involved in adverse pregnancy outcomes. Fusobacterium …
Glycan microarrays as chemical tools for identifying glycan recognition by immune proteins
Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost
every aspect of immunology. Investigations of the interactions between glycans and GBPs …
every aspect of immunology. Investigations of the interactions between glycans and GBPs …