High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

The sweet spot: defining virus–sialic acid interactions

JE Stencel-Baerenwald, K Reiss, DM Reiter… - Nature Reviews …, 2014 - nature.com
Viral infections are initiated by attachment of the virus to host cell surface receptors,
including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan …

A useful guide to lectin binding: machine-learning directed annotation of 57 unique lectin specificities

D Bojar, L Meche, G Meng, W Eng, DF Smith… - ACS Chemical …, 2022 - ACS Publications
Glycans are critical to every facet of biology and medicine, from viral infections to
embryogenesis. Tools to study glycans are rapidly evolving; however, the majority of our …

Probing the binding specificities of human Siglecs by cell-based glycan arrays

C Büll, R Nason, L Sun, J Van Coillie… - Proceedings of the …, 2021 - National Acad Sciences
Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune
system and a few other cell types capable of modulating immune cell functions upon …

An atlas of human glycosylation pathways enables display of the human glycome by gene engineered cells

Y Narimatsu, HJ Joshi, R Nason, J Van Coillie… - Molecular cell, 2019 - cell.com
The structural diversity of glycans on cells—the glycome—is vast and complex to decipher.
Glycan arrays display oligosaccharides and are used to report glycan hapten binding …

Involvement of a non-human sialic acid in human cancer

AN Samraj, H Läubli, N Varki, A Varki - Frontiers in oncology, 2014 - frontiersin.org
Sialic acids are common monosaccharides that are widely expressed as outer terminal units
on all vertebrate cell surfaces, and play fundamental roles in cell–cell and cell …

The interaction of the gut microbiota with the mucus barrier in health and disease in human

AP Corfield - Microorganisms, 2018 - mdpi.com
Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and
other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for …

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

K Kawanishi, C Dhar, R Do, N Varki… - Proceedings of the …, 2019 - National Acad Sciences
Cardiovascular disease (CVD) events due to atherosclerosis cause one-third of worldwide
deaths and risk factors include physical inactivity, age, dyslipidemia, hypertension, diabetes …

[HTML][HTML] Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc

L Parhi, J Abed, A Shhadeh, T Alon-Maimon, S Udi… - Cell Reports, 2022 - cell.com
While the existence of an indigenous placental microbiota remains controversial, several
pathogens are known to be involved in adverse pregnancy outcomes. Fusobacterium …

Glycan microarrays as chemical tools for identifying glycan recognition by immune proteins

C Gao, M Wei, TR McKitrick, AM McQuillan… - Frontiers in …, 2019 - frontiersin.org
Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost
every aspect of immunology. Investigations of the interactions between glycans and GBPs …