The Golgi apparatus is at the center of protein processing and trafficking in normal cells.
Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor …

Collagens are fundamental constituents of the extracellular matrix and are the most
abundant proteins in mammals. Collagens belong to the family of fibrous or fiber-forming …

Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of develo** lung cancer
compared with the general population. The morbidity of lung cancer in IPF patient ranges …

Abstract Lysyl hydroxylase 2 (LH2) is a member of LH family that catalyzes the hydroxylation
of lysine (Lys) residues on collagen, and this particular isozyme has been implicated in …

Hydroxylysine glycosylations are post-translational modifications (PTMs) essential for the
maturation and homeostasis of fibrillar and non-fibrillar collagen molecules. The …

Lysyl hydroxylase 2 (LH2) catalyzes the formation of highly stable hydroxylysine aldehyde-
derived collagen cross-links (HLCCs), thus promoting lung cancer metastasis through its …

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer
worldwide and incidence rates are continuing to rise globally. HNSCC patient prognosis is …

Simple Summary A common feature of tumor types such as breast cancer, prostate cancer,
pancreatic cancer, and soft-tissue sarcoma is the deposition of collagen-rich tissue called …

The four biological enzymes encompassing alkaline phosphatase (ALP), aminopeptidase N
(APN), γ-glutamyl transferase (GGT), and Cathepsin B (CTB), play a pivotal role in a myriad …

Collagens are the most abundant proteins in the body and among the most biosynthetically
complex. A molecular ensemble of over 20 endoplasmic reticulum resident proteins …