Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …

Simple Summary Breast cancer patients often receive anti-hormonal treatment if their tumor
is positive for the Estrogen Receptor (ER), but tumors may become resistant to this therapy …

Objective: To evaluate the efficacy and treatment rationale of Hürthle cell carcinoma (HCC)
following a patient with progressive and metastatic HCC. HCC was recently shown to harbor …

The development of sequencing-by-synthesis (1) catapulted the field of genomics into a new
age. The ability to immobilise each DNA molecule on the surface of a chip, and continuously …

Cancer genomes harbor structural variants (SV), producing various driver alterations and
reflecting the signatures of mutagenesis. With the fast accumulating whole genome …

Technological advances in the ability to read the human genome have accelerated the
speed of sequencing, such that today we can perform whole genome sequencing (WGS) in …