The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular
chaperones. According to their size they have been classified into the following families; …

Glycolytic metabolism may account for antitumor immunity failure. Pyruvate kinase M2
(PKM2) and platelet phosphofructokinase (PFKP), two key enzymes involved in the …

The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Traditional anticancer chemotherapeutics targeting DNA replication and cell division have
severe side effects, but they have proved to be highly successful in treating some cancers …

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report
that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that …

Background In vivo metastasis assays have traditionally been performed in mice, but the
process is inefficient and costly. However, since zebrafish do not develop an adaptive …

Hsp70s are among the most highly conserved proteins in all of biology. Through an iterative
binding and release of exposed hydrophobic residues on client proteins, Hsp70s can …

In recent years, natural products gained popularity with their anti-inflammatory and
antioxidant effects mediated by chemical compounds within their composition. Study results …

Abstract Heat shock protein 70 (HSP70) is a highly conserved protein composed of
nucleotide-binding domains (NBD) and C-terminal substrate binding domain (SBD) that can …