New technologies for imaging molecules, particularly optical technologies, are increasingly
being used to understand the complexity, diversity and in vivo behaviour of cancers.'Omic' …

Morphological observations have driven the course of biology ever since the first
microscope was built in the late sixteenth century. Molecular imaging is a rapidly emerging …

In cancer treatment, apoptosis is a well-recognized cell death mechanism through which
cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic …

Optical sensing of specific molecular targets and pathways deep inside living mice has
become possible as a result of a number of advances. These include design of …

The term molecular imaging can be broadly defined as the in vivo characterization and
measurement of biologic processes at the cellular and molecular level. In contradistinction to …

Mature donor T cells cause graft-versus-host disease (GVHD), but they are also the main
mediators of the beneficial graft-versus-tumor (GVT) activity of allogeneic bone marrow …

Multipotent mesenchymal stromal/stem cells (MSC) have shown potential clinical utility.
However, previous assessments of MSC behavior in recipients have relied on visual …

A recent development in biomedical imaging is the non-invasive map** of molecular
events in intact tissues using fluorescence. Underpinning to this development is the …

Biomedical photonics is defined as the science of harnessing light and other forms of radiant
energy to address problems in medicine and biology. The field has experienced explosive …

To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated
human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled …