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Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
The link between circulating follicular helper T cells and autoimmunity
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …
centres that allow affinity maturation of antibody responses. Although usually located in …
Universal recording of immune cell interactions in vivo
Immune cells rely on transient physical interactions with other immune and non-immune
populations to regulate their function. To study these 'kiss-and-run'interactions directly in …
populations to regulate their function. To study these 'kiss-and-run'interactions directly in …
T follicular helper cell biology: a decade of discovery and diseases
Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
[HTML][HTML] Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response
T cells mediate antigen-specific immune responses to disease through the specificity and
diversity of their clonotypic T cell receptors (TCRs). Determining the spatial distributions of T …
diversity of their clonotypic T cell receptors (TCRs). Determining the spatial distributions of T …
[HTML][HTML] Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses
that are higher in magnitude and affinity than the primary response. These involve …
that are higher in magnitude and affinity than the primary response. These involve …
[HTML][HTML] Germinal center B cell dynamics
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …
such are vitally important for humoral immunity. The study of GC biology has undergone a …
Bcl6-mediated transcriptional regulation of follicular helper T cells (TFH)
Follicular helper T cells (T FH) are essential B cell-help providers in the formation of
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …
germinal centers (GCs), affinity maturation of GC B cells, differentiation of high-affinity …
PD-1 controls follicular T helper cell positioning and function
Follicular T helper (Tfh) cells highly express the programmed cell death-1 (PD-1) molecule.
Whereas inhibition of T cell receptor (TCR) signaling and CD28 co-stimulation is thought to …
Whereas inhibition of T cell receptor (TCR) signaling and CD28 co-stimulation is thought to …
Adaptive immune responses to primary and secondary dengue virus infections
Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the
circulation of multiple serotypes, global expansion of the disease and recent gains in …
circulation of multiple serotypes, global expansion of the disease and recent gains in …