Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate …

SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice
carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations …

Glutamate is the major excitatory neurotransmitter in the central nervous system.
Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs) …

Fine orchestration of excitatory and inhibitory synaptic development is required for normal
brain function, and alterations may cause neurodevelopmental disorders. Using sparse …

The GluD1 gene is associated with susceptibility for schizophrenia, autism, depression, and
bipolar disorder. However, the function of GluD1 and how it is involved in these conditions …

Ionotropic orphan delta (GluD) receptors are not gated by glutamate or any other
endogenous ligand but are grouped with ionotropic glutamate receptors (iGluRs) based on …

The dorsal raphe nucleus is the predominant source of central serotonin, where neuronal
activity regulates complex emotional behaviors. Action potential firing of serotonin dorsal …

Identifying robust markers for predicting the onset of psychosis has been a key challenge for
early detection research. Persecutory delusions are core symptoms of psychosis, and social …

In the cerebellum, GluD2 is exclusively expressed in Purkinje cells, where it regulates
synapse formation and regeneration, synaptic plasticity, and motor learning. Delayed …