Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

[HTML][HTML] Cannabinoids in the treatment of epilepsy: hard evidence at last?

E Perucca - Journal of epilepsy research, 2017 - ncbi.nlm.nih.gov
The interest in cannabis-based products for the treatment of refractory epilepsy has
skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ …

Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies

DS Reddy - Experimental neurology, 2023 - Elsevier
Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …

Cannabis and its secondary metabolites: their use as therapeutic drugs, toxicological aspects, and analytical determination

J Gonçalves, T Rosado, S Soares, AY Simão… - Medicines, 2019 - mdpi.com
Although the medicinal properties of Cannabis species have been known for centuries, the
interest on its main active secondary metabolites as therapeutic alternatives for several …

Pharmacological and therapeutic properties of cannabidiol for epilepsy

V Franco, E Perucca - Drugs, 2019 - Springer
Cannabidiol (CBD) is a major active component of the Cannabis plant, which, unlike
tetrahydrocannabinol (THC), is devoid of euphoria-inducing properties. During the last 10 …

Safety, efficacy, and mechanisms of action of cannabinoids in neurological disorders

D Friedman, JA French, M Maccarrone - The Lancet Neurology, 2019 - thelancet.com
In the past two decades, there has been an increasing interest in the therapeutic potential of
cannabinoids for neurological disorders such as epilepsy, multiple sclerosis, pain, and …

Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination, and related clinical implications

E Perucca, M Bialer - CNS drugs, 2020 - Springer
This article provides a critical appraisal of the available evidence concerning clinical
exposure to orally administered cannabidiol (CBD), with special reference to factors …

Emerging use of epidiolex (cannabidiol) in epilepsy

R Abu-Sawwa, B Scutt, Y Park - The Journal of Pediatric …, 2020 - meridian.allenpress.com
The first plant-derived, purified pharmaceutical-grade cannabidiol (CBD) medication,
Epidiolex, was approved in the United States by the FDA on June 25, 2018. Its approval for …

Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

P Alves, C Amaral, N Teixeira… - Pharmacological …, 2020 - Elsevier
Cannabis is the most used illicit drug worldwide and its medicinal use is under discussion,
being regulated in several countries. However, the psychotropic effects of Δ 9 …