Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …

High-grade gliomas (HGG) are a devastating group of cancers, and represent the leading
cause of brain tumour-related death in both children and adults. Therapies aimed at …

ADAM10 (A Disintegrin and Metalloproteinase 10) has been identified as the major
physiological alpha-secretase in neurons, responsible for cleaving APP in a non …

Abstract Background Tenascin-C (TNC), an extracellular matrix protein overexpressed in
malignant gliomas, stimulates invasion of conventional glioma cell lines (U251, U87) …

Malignant gliomas are highly invasive, proliferative, and resistant to treatment. Previously,
we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of …

Background There are emerging reports that the family of a disintegrin and
metalloproteinases (ADAM) are involved in the maintenance of the malignant phenotype of …

Glioblastoma is the most common form of primary malignant brain tumour. These tumours
are highly proliferative and infiltrative resulting in a median patient survival of only 14 …

In recent years, it became clear that a better understanding of the interactions among the
main elements involved in the cancer network is necessary for the treatment of cancer and …

No biomarker can effectively screen for early gastric cancer (EGC). Players in the A
disintegrin and metalloproteinase (ADAM)-natural killer group 2 member D (NKG2D) …

Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human
cancer with low survival rates because of its highly invasive nature. In recent years, there …