Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Recent discoveries of rare variants of human APOE may shed light on novel therapeutic
strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective …

The accumulation of lipid droplets (LDs) in aging and Alzheimer's disease brains is
considered a pathological phenomenon with unresolved cellular and molecular …

The greatest risk factor for neurodegeneration is the aging of the multiple cell types of
human CNS, among which microglia are important because they are the “sentinels” of …

Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's
disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the …

Alzheimer's disease is a progressive neurodegenerative disorder that affects memory and
cognitive abilities, affecting millions of people around the world. Current treatments focus on …

APOE ε4 is the major genetic risk factor for sporadic Alzheimer's disease (AD). Although
APOE ε4 is known to promote Aβ pathology, recent data also support an effect of APOE …

The brain's primary immune cells, microglia, are a leading causal cell type in Alzheimer's
disease (AD). Yet, the mechanisms by which microglia can drive neurodegeneration remain …

The unfavorable prognosis of many neurological conditions could be attributed to limited
tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while …