Uveitis is one of the leading causes of blindness worldwide. Noninfectious uveitis may be
associated with other systemic conditions, such as human leukocyte antigen B27-related …

The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the
systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve …

Uveitis, a group of conditions characterized by intraocular inflammation, is a major cause of
sight loss in the working population. Most uveitis seen in Western countries is noninfectious …

Biologic therapies have increased the treatment options for sight-threatening uveitis. Despite
experimental rationale, the lack of evidence from randomized controlled studies limits our …

Non-infectious uveitis (NIU) is a disorder with various etiologies and is characterized by eye
inflammation, mainly affecting people of working age. An accurate diagnosis of NIU is crucial …

A complex web of dynamic relationships between innate and adaptive immunity is now
evident for many autoinflammatory and autoimmune disorders, the first deriving from …

The TNF-α inhibitors adalimumab and infliximab have the greatest body of data supporting
their use in NIU. These agents are considered second-line therapy for most forms of NIU but …

Иммуновоспалительные заболевания человека в зависимости от преобладающих
механизмов активации иммунитета разделяются на две основные категории …

In vertebrates, the innate and adaptive immune systems have evolved seamlessly to protect
the host by rapidly responding to danger signals, eliminating pathogens and creating …

Abstract Objective Monogenic Autoinflammatory diseases (AIDs) are a broad spectrum of
rare hereditary diseases whose ocular involvement has not been well characterized yet …