As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is
a ligand-activated transcription factor that plays a crucial role in the metabolism of …

Osteoarthritis (OA) is a common degenerative joint disease urgently needing effective
treatments. Bone marrow mesenchymal stromal cell-derived exosomes (Exo) are …

Numerous small-molecule amines (SMAs) play critical roles in maintaining bone
homeostasis and promoting bone regeneration regardless of whether they are applied as …

Osteoclasts are multinucleated giant cells with the ability to degrade bone tissue, and are
closely related to abnormal bone metabolic diseases. Endoplasmic reticulum (ER) is an …

Osteoarthritis (OA) is a degenerative disease characterized by progressive loss of cartilage,
osteophyte formation and subchondral bone sclerosis. Although some animal experiments …

Introduction: Disruptions of extracellular matrix (ECM) degradation homeostasis play a
significant role in the pathogenesis of osteoarthritis (OA). Matrix metalloproteinase 13 …

Bone marrow mesenchymal stem cells (BMSCs) differentiation dysfunction is a common
pathological phenotype of several prevalent metabolic and genetic bone diseases. Pyruvate …

Vascular resident endothelial progenitor cells (VR‐EPCs) have a certain ability to
differentiate into endothelial cells (ECs) and participate in the process of angiogenesis …

COVID-19, caused by the novel coronavirus SARS-CoV-2, has spread globally and caused
serious social and economic problems. The WHO has declared this outbreak a pandemic …

Osteoporosis is a systemic and endocrine bone disorder distinguished by declined bone
mineral density, compromised bone strength, and destruction of trabecular structure. The …