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Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …
been extensively researched since the landmark report by Morpurgo (1897) of “work …
Crosstalk between metabolism and circadian clocks
Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …
Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors
Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass
and function. This disorder has been associated with a range of adverse health outcomes …
and function. This disorder has been associated with a range of adverse health outcomes …
Metabolism and exercise: the skeletal muscle clock takes centre stage
Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …
increasing interest over the past two decades. The molecular clock, which is present in …
Endocrine crosstalk between skeletal muscle and the brain
Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …
[HTML][HTML] Sleep, circadian biology and skeletal muscle interactions: Implications for metabolic health
There currently exists a modern epidemic of sleep loss, triggered by the changing demands
of our 21st century lifestyle that embrace 'round-the-clock'remote working hours, access to …
of our 21st century lifestyle that embrace 'round-the-clock'remote working hours, access to …
Circadian etiology of type 2 diabetes mellitus
The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …
and preventative strategies to attenuate expansion of this debilitating disease. Evidence …
Circadian rhythms, sleep, and metabolism
The discovery of the genetic basis for circadian rhythms has expanded our knowledge of the
temporal organization of behavior and physiology. The observations that the circadian gene …
temporal organization of behavior and physiology. The observations that the circadian gene …
[HTML][HTML] Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock
Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal
muscle clock has never been explored. We generated conditional and inducible mouse …
muscle clock has never been explored. We generated conditional and inducible mouse …
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …