The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

This article reviews and synthesizes research on reward processing in schizophrenia, which
has begun to provide important insights into the cognitive and neural mechanisms …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Importance Abnormal reward processing is suggested to underlie the formation of psychotic
symptoms, likely driven by elevated ventral striatal (VS) dopamine levels. Functional …

We propose that schizophrenia involves a combination of decreased phasic dopamine
responses for relevant stimuli and increased spontaneous phasic dopamine release. Using …

Substance use disorders occur commonly in patients with schizophrenia and dramatically
worsen their overall clinical course. While the exact mechanisms contributing to substance …

A range of emotional and motivation impairments have long been clinically documented in
people with schizophrenia, and there has been a resurgence of interest in understanding …

Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

Dysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of
schizophrenia (SZ), yet its precise contributions to different stages of reward processing and …

In the DSM5, negative symptoms are 1 of the 5 core dimensions of psychopathology
evaluated for schizophrenia. However, negative symptoms are not pathognomonic—they …