Synthetic biology: bottom-up assembly of molecular systems

S Hirschi, TR Ward, WP Meier, DJ Müller… - Chemical …, 2022 - ACS Publications
The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …

Artificial cells: past, present and future

W Jiang, Z Wu, Z Gao, M Wan, M Zhou, C Mao… - ACS nano, 2022 - ACS Publications
Artificial cells are constructed to imitate natural cells and allow researchers to explore
biological process and the origin of life. The construction methods for artificial cells, through …

Synthetic cells: from simple bio‐inspired modules to sophisticated integrated systems

C Guindani, LC da Silva, S Cao, T Ivanov… - Angewandte …, 2022 - Wiley Online Library
Bottom‐up synthetic biology is the science of building systems that mimic the structure and
function of living cells from scratch. To do this, researchers combine tools from chemistry …

Active particles induce large shape deformations in giant lipid vesicles

HR Vutukuri, M Hoore, C Abaurrea-Velasco… - Nature, 2020 - nature.com
Biological cells generate intricate structures by sculpting their membrane from within to
actively sense and respond to external stimuli or to explore their environment,,–. Several …

Biomolecular condensates mediate bending and scission of endosome membranes

Y Wang, S Li, M Mokbel, AI May, Z Liang, Y Zeng… - Nature, 2024 - nature.com
Multivesicular bodies are key endosomal compartments implicated in cellular quality control
through their degradation of membrane-bound cargo proteins,–. The ATP-consuming …

Versatile phospholipid assemblies for functional synthetic cells and artificial tissues

X Wang, H Du, Z Wang, W Mu, X Han - Advanced materials, 2021 - Wiley Online Library
The bottom‐up construction of a synthetic cell from nonliving building blocks capable of
mimicking cellular properties and behaviors helps to understand the particular biophysical …

Core-shell microparticles: From rational engineering to diverse applications

X Zhang, Q Qu, A Zhou, Y Wang, J Zhang… - Advances in Colloid and …, 2022 - Elsevier
Core-shell microparticles, composed of solid, liquid, or gas bubbles surrounded by a
protective shell, are gaining considerable attention as intelligent and versatile carriers that …

[HTML][HTML] Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

I Anastasia, N Ilacqua, A Raimondi, P Lemieux… - Cell Reports, 2021 - cell.com
Contacts between organelles create microdomains that play major roles in regulating key
intracellular activities and signaling pathways, but whether they also regulate systemic …

Interfacing living and synthetic cells as an emerging frontier in synthetic biology

Y Elani - Angewandte Chemie, 2021 - Wiley Online Library
The construction of artificial cells from inanimate molecular building blocks is one of the
grand challenges of our time. In addition to being used as simplified cell models to decipher …

Growth, replication and division enable evolution of coacervate protocells

AD Slootbeek, MHI van Haren, IBA Smokers… - Chemical …, 2022 - pubs.rsc.org
Living and proliferating cells undergo repeated cycles of growth, replication and division, all
orchestrated by complex molecular networks. How a minimal cell cycle emerged and helped …