[HTML][HTML] Cancer metastases: challenges and opportunities

X Guan - Acta pharmaceutica sinica B, 2015 - Elsevier
Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for
about 90% of cancer deaths. Although cancer survival rate has been significantly improved …

IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma

J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

microRNA therapeutics in cancer—an emerging concept

MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …

Roles of circRNAs in the tumour microenvironment

Q Zhang, W Wang, Q Zhou, C Chen, W Yuan, J Liu… - Molecular cancer, 2020 - Springer
The tumour microenvironment (TME) constitutes the area surrounding the tumour during its
development and has been demonstrated to play roles in cancer-related diseases through …

Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis

A Pardo, S Cabrera, M Maldonado, M Selman - Respiratory research, 2016 - Springer
Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating lung disorder of
unknown origin, with very poor prognosis and no effective treatment. The disease is …

A step-by-step microRNA guide to cancer development and metastasis

GS Markopoulos, E Roupakia, M Tokamani… - Cellular Oncology, 2017 - Springer
Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer

M Hu, S Zhu, S **ong, X Xue… - Oncology reports, 2019 - spandidos-publications.com
Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …

Immune modulatory microRNAs involved in tumor attack and tumor immune escape

SB Eichmüller, W Osen, O Mandelboim… - JNCI: Journal of the …, 2017 - academic.oup.com
Current therapies against cancer utilize the patient's immune system for tumor eradication.
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …

The fundamental role of mechanical properties in the progression of cancer disease and inflammation

CT Mierke - Reports on Progress in Physics, 2014 - iopscience.iop.org
The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

Expression of adipocyte/macrophage fatty acid–binding protein in tumor-associated macrophages promotes breast cancer progression

J Hao, F Yan, Y Zhang, A Triplett, Y Zhang, DA Schultz… - Cancer research, 2018 - AACR
Tumor-associated macrophages (TAM) play a critical role in cancer development and
progression. However, the heterogeneity of TAM presents a major challenge to identify …