The Hippo signaling pathway inhibits the activity of the oncogenic YAP (Yes-associated
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …

Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays
a pivotal role in organ size control and tumor suppression by inhibiting proliferation and …

As highly conserved among diverse species, Hippo signaling pathway regulates various
biological processes, including development, cell proliferation, stem cell function, tissue …

Cancer metastasis is a complex process influenced by various factors, including epithelial-
mesenchymal transition (EMT), tumor cell proliferation, tumor microenvironment, and cellular …

Lung cancer is the primary contributor to cancer-related deaths globally, and non-small cell
lung cancer (NSCLC) constitutes around 85% of all lung cancer cases. Recently, the …

TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein
of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in …

As the second most common malignant tumor in the urinary system, renal cell carcinoma
(RCC) is imperative to explore its early diagnostic markers and therapeutic targets …

Abstract SET domain containing 7 (SETD7), a member of histone methyltransferases, is
abnormally expressed in multiple tumor types. However, the biological function and …

Substantial progress has been made in cancer biology and treatment in recent years, but the
clinical outcome of patients with renal cell carcinoma (RCC) remains unsatisfactory. The …

Purpose Renal cell carcinoma (RCC) is a common malignancy, with patients frequently
diagnosed at an advanced stage due to the absence of sufficiently sensitive detection …