Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

The altered metabolism of tumors has been considered a target for anticancer therapy.
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …

Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals
triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that …

R loops arising during transcription induce genomic instability, but how cells respond to the
R loop-associated genomic stress is still poorly understood. Here, we show that cells …

A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate
(dNTP) levels within a range that is optimal for chromosomal replication. Since DNA …

Glioblastoma is the most common and aggressive type of cancer in the brain; its poor
prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent …

The metabolic plasticity of mitochondria ensures cell development, differentiation, and
survival. The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress …

While many functions of the p53 tumor suppressor affect mitochondrial processes, the role of
altered mitochondrial physiology in a modulation of p53 response remains unclear. As …

Members of the caspase family are well known for their roles in the initiation and execution
of cell death. Due to their function in the removal of damaged cells that could otherwise …