Selective autophagy performs an array of tasks to maintain intracellular homeostasis,
sterility, and organellar and cellular functionality. The fidelity of these processes depends on …

Several curcuminoids have been identified from rhizome of the common spice Curcuma
longa (Zingaberaceae) and related plant species. Curcuminoids are known to display …

Despite the importance of AKT overactivation in tumor progression, results from clinical trials
of various AKT inhibitors remain suboptimal, suggesting that AKT-driven tumor metastasis …

Innate immune detection and subsequent immune responses rely on the initial recognition
of pathogen specific molecular motifs. Foreign nucleic acids are key structures recognised …

Tripartite Motif-containing protein 16 (TRIM16) is a member of a large family of tripartite motif
(TRIM) proteins, that has been implicated in the pathogenesis of multiple cancers. However …

Although selective BRAF inhibitors and novel immunotherapies have improved short-term
treatment responses in metastatic melanoma patients, acquired resistance to these …

Nonalcoholic steatohepatitis (NASH)-related hepatocellular carcinoma and liver disorders
have become the leading causes for the need of liver transplantation in developed …

Abstract Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil
(RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant …

Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with
increasing morbidity and mortality, with limited treatment options for advanced disease …

Neuroblastoma is the most common solid tumor in childhood and represents 15% of all
children's cancer deaths. We have previously demonstrated that tripartite motif 16 (TRIM16) …