The beginning of meiosis in mammalian female germ cells: A never-ending story of intrinsic and extrinsic factors
Meiosis is the unique division of germ cells resulting in the recombination of the maternal
and paternal genomes and the production of haploid gametes. In mammals, it begins during …
and paternal genomes and the production of haploid gametes. In mammals, it begins during …
DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis
DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …
of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the …
Epigenetic markers in the embryonal germ cell development and spermatogenesis
Spermatogenesis is the process of generation of male reproductive cells from
spermatogonial stem cells in the seminiferous epithelium of the testis. During …
spermatogonial stem cells in the seminiferous epithelium of the testis. During …
Sex-specific chromatin remodelling safeguards transcription in germ cells
Stability of the epigenetic landscape underpins maintenance of the cell-type-specific
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …
Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin
Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror
gene expression programs of the next generation. However, it remains largely unknown how …
gene expression programs of the next generation. However, it remains largely unknown how …
Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions
Ten-eleven translocation (TET) enzymes iteratively oxidize 5-methylcytosine (5mC) to
generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine to …
generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine to …
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations
Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic
pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male …
pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male …
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes
E Aizawa, EA Ozonov, YK Kawamura… - The EMBO …, 2023 - embopress.org
Recent studies have reported the differentiation of pluripotent cells into oocytes in vitro.
However, the developmental competence of in vitro‐generated oocytes remains low. Here …
However, the developmental competence of in vitro‐generated oocytes remains low. Here …
Toxicoepigenetics and environmental health: Challenges and opportunities
The rapidly growing field of toxicoepigenetics seeks to understand how toxicant exposures
interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field …
interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field …
DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells
Background Genome-wide DNA demethylation occurs in mammalian primordial germ cells
(PGCs) as part of the epigenetic reprogramming important for gametogenesis and resetting …
(PGCs) as part of the epigenetic reprogramming important for gametogenesis and resetting …