DNA double-strand break repair-pathway choice in somatic mammalian cells
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …
genomic stability. However, if deployed in an inappropriate cellular context, these same …
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
DNA damage sensing by the ATM and ATR kinases
In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
J Lukas, C Lukas, J Bartek - Nature cell biology, 2011 - nature.com
Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …
damage, interest in the changes to chromatin induced by DNA damage has exploded, and a …
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
Class-switch DNA recombination (CSR) of the immunoglobulin heavy chain (IGH) locus is
central to the maturation of the antibody response and crucially requires the cytidine …
central to the maturation of the antibody response and crucially requires the cytidine …
Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage
L Deriano, DB Roth - Annual review of genetics, 2013 - annualreviews.org
DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic
integrity. Failure to repair a DSB has deleterious consequences, including cell death …
integrity. Failure to repair a DSB has deleterious consequences, including cell death …
[HTML][HTML] Mechanisms of programmed DNA lesions and genomic instability in the immune system
Chromosomal translocations involving antigen receptor loci are common in lymphoid
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …
Repair of double-strand breaks by end joining
Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
Double strand break repair functions of histone H2AX
R Scully, A **e - … Research/Fundamental and Molecular Mechanisms of …, 2013 - Elsevier
Chromosomal double strand breaks provoke an extensive reaction in neighboring
chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal …
chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal …
Function and molecular mechanism of the DNA damage response in immunity and cancer immunotherapy
The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …