Scaffold-based 3D cell culture models in cancer research
Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …
research, offering significant advantages over traditional two-dimensional (2D) cell culture …
Opportunities for microphysiological systems in toxicity testing of new drug modalities
TI Maulana, NR Wevers, T Kristoforus… - Annual Review of …, 2024 - annualreviews.org
New drug modalities offer life-saving benefits for patients through access to previously
undruggable targets. Yet these modalities pose a challenge for the pharmaceutical industry …
undruggable targets. Yet these modalities pose a challenge for the pharmaceutical industry …
[PDF][PDF] Guidance document on good cell and tissue culture practice 2.0 (GCCP 2.0)
Abstract Good Cell and Tissue Culture Practice (GCCP) 2.0 is an updated guidance
document from GCCP 1.0 (published by ECVAM in 2005), which was developed for practical …
document from GCCP 1.0 (published by ECVAM in 2005), which was developed for practical …
In Vitro Research Reproducibility: Kee** Up High Standards
C Hirsch, S Schildknecht - Frontiers in pharmacology, 2019 - frontiersin.org
Concern regarding the reproducibility of observations in life science research has emerged
in recent years, particularly in view of unfavorable experiences with preclinical in vivo …
in recent years, particularly in view of unfavorable experiences with preclinical in vivo …
Advanced good cell culture practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
A major reason for the current reproducibility crisis in the life sciences is the poor
implementation of quality control measures and reporting standards. Improvement is …
implementation of quality control measures and reporting standards. Improvement is …
The exposome: a new approach for risk assessment
F Sillé, S Karakitsios, A Kleensang, K Koehler… - 2020 - kops.uni-konstanz.de
Complementing the human genome with an exposome reflects the increasingly obvious
impact of environmental exposure, which far exceeds the role of genetics, on human health …
impact of environmental exposure, which far exceeds the role of genetics, on human health …
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D
models like reaggregates, spheroids, and organoids, improved with bioengineering like …
models like reaggregates, spheroids, and organoids, improved with bioengineering like …
Toward good in vitro reporting standards
A good experiment reported badly is worthless. Meaningful contributions to the body of
science are made by sharing the full methodology and results so that they can be evaluated …
science are made by sharing the full methodology and results so that they can be evaluated …
An insight into impact of nanomaterials toxicity on human health
In recent years, advances in nanotechnology have significantly influenced electronics
manufacturing, industrial processes, and medical research. Various industries have seen a …
manufacturing, industrial processes, and medical research. Various industries have seen a …
Optimizing drug discovery by investigative toxicology: current and future trends
M Beilmann, H Boonen, A Czich, G Dear… - ALTEX-Alternatives to …, 2019 - altex.org
Investigative toxicology describes the de-risking and mechanistic elucidation of toxicities,
supporting early safety decisions in the pharmaceutical industry. Recently, investigative …
supporting early safety decisions in the pharmaceutical industry. Recently, investigative …