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Progressive multiple sclerosis: from pathophysiology to therapeutic strategies
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …
involves demyelination and axonal degeneration. Although substantial progress has been …
Ion channels in innate and adaptive immunity
Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …
[HTML][HTML] Peptide therapeutics from venom: Current status and potential
MW Pennington, A Czerwinski, RS Norton - Bioorganic & medicinal …, 2018 - Elsevier
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
Scorpion venom components as potential candidates for drug development
E Ortiz, GB Gurrola, EF Schwartz, LD Possani - Toxicon, 2015 - Elsevier
Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …
for human beings, including death. Neurotoxins present in their venoms are responsible for …
Voltage-gated potassium channels as therapeutic targets
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …
diverse physiological processes ranging from repolarization of neuronal and cardiac action …
Ion channels and transporters in lymphocyte function and immunity
S Feske, EY Skolnik, M Prakriya - Nature Reviews Immunology, 2012 - nature.com
Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …
Calcium signalling in lymphocyte activation and disease
S Feske - Nature Reviews Immunology, 2007 - nature.com
Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …
differentiation, gene transcription and effector functions. An increase in intracellular levels of …
Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?
MB Lutz, G Schuler - Trends in immunology, 2002 - cell.com
Dendritic cells (DCs) are currently divided into tolerogenic immature and immunogenic
mature differentiation stages. However, recent findings challenge this model by reporting …
mature differentiation stages. However, recent findings challenge this model by reporting …
Therapeutic potential of venom peptides
RJ Lewis, ML Garcia - Nature reviews drug discovery, 2003 - nature.com
Venomous animals have evolved a vast array of peptide toxins for prey capture and
defence. These peptides are directed against a wide variety of pharmacological targets …
defence. These peptides are directed against a wide variety of pharmacological targets …