Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Abstract α-Synuclein aggregation is a critical molecular process that underpins the
pathogenesis of Parkinson's disease. Aggregates may originate at synaptic terminals as a …

The synucleins are a family of natively unfolded (or intrinsically unstructured) proteins
consisting of α-, β-, and γ-synuclein involved in neurodegenerative diseases and cancer …

Aggregation of α-synuclein (α-syn) into amyloid fibrils is closely associated with Parkinson's
disease (PD). Familial mutations or posttranslational truncations in α-syn are known as risk …

Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of
Parkinson's disease. Although the intensely anionic C-terminal domain (CTD) of αSN does …

Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …

Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the
primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral …

Abstract α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …

The misfolding and pathological aggregation of α-synuclein forming insoluble amyloid
deposits is associated with Parkinson's disease, the second most common …