Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and
inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has …

Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively
worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in …

Herein, a mechanochemically triggered C–H arylation of coumarins, quinoline-N-oxides,
and uracil molecules with aryl thianthrenium salts is described. Aryl thianthrenium salts are …

A novel photocatalysis to construct the 3-acyl-4-arylcoumarin framework from simple
aldehyde with ynoate is described. The reaction proceeded through an acyl radical …

Abnormal protein aggregation has been linked to many neurodegenerative diseases,
including Parkinson's disease (PD). The main pathological hallmark of PD is the formation of …

A new series of coumarin based aminopyran derivatives were designed, synthesized and
evaluated for their preclinical antidepressant effect on Swiss albino mice. Among the series …

We demonstrate a facile one pot approach for the regioselective synthesis of chromeno [4, 3-
b] quinolin-6-one derivatives in excellent yields under microwave (MW) irradiation. This …

A facile regioselective metal-free direct α-arylation of coumarins and 2-pyridones is
achieved by the reaction of coumarins and 2-pyridones with phenylhydrazine in good yields …

A series of tacrine-pyrazolo [3, 4-b] pyridine hybrids were synthesised and evaluated as dual
cholinesterase (ChE) and phosphodiesterase 4D (PDE4D) inhibitors for the treatment of …