Mass spectrometry imaging (MSI) is a powerful tool that enables untargeted investigations
into the spatial distribution of molecular species in a variety of samples. It has the capability …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Studying cell heterogeneity can provide a deeper understanding of biological activities, but
appropriate studies cannot be performed using traditional bulk analysis methods. The …

Significance: Despite the importance of the cell membrane in regulation of drug activity, the
influence of drug treatments on its physical properties is still poorly understood. The …

Lipids are essential cellular components forming membranes, serving as energy reserves,
and acting as chemical messengers. Dysfunction in lipid metabolism and signaling is …

The variation among individual cells plays a significant role in many biological functions.
Single-cell analysis is advantageous for gaining insight into intricate biochemical …

Boron has been employed in materials science as a marker for imaging specific structures
by electron energy loss spectroscopy (EELS) or secondary ion mass spectrometry (SIMS). It …

Currently, single-cell analysis has become increasingly important. It can reveal cell-to-cell
variances in a heterogeneous cell population and obtain a rare but important cytological …

Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations
fuel the progression of malignant transformation, such as uncontrolled proliferation …

Cancer cells survive treatment through mechanisms that remain unclear. This study
investigates the chemical changes that occur in cancer cells after treatment, focusing on lipid …