Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative
stress. Current dressings that promote chronic wound healing either require additional …

With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

The universal increase in the number of patients with nonhealing skin wounds imposes a
huge social and economic burden on the patients and healthcare systems. Although, the …

Infectious diseases are a major driver of morbidity and mortality globally. Treatment of
malaria, tuberculosis and human immunodeficiency virus infection are particularly …

Skin wound healing shows an extraordinary cellular function mechanism, unique in nature
and involving the interaction of several cells, growth factors and cytokines. Physiological …

Conspectus Diabetic foot ulcers (DFUs) are chronic wounds that develop in 30% of diabetic
patients. In DFUs, the normal wound healing process consisting of inflammation …

Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease
has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm …

Although new antibiofilm agents have been developed to prevent and eliminate pathogenic
biofilms, their widespread clinical use is hindered by poor biocompatibility and …