Boranes and borohydride reagents have found utility in synthesis routes to a number of
pharmaceutical and other products. Boron reagents have become increasingly important for …

Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze
the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building …

Fluoxetine (Prozac) was the first major breakthrough for the treatment of depression since
the introduction of tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors …

Cascade biocatalysis via intracellular epoxidation and hydrolysis was developed as a green
and efficient method for enantioselective dihydroxylation of aryl olefins to prepare chiral …

Enantioselective hydrogenation using chiral complexes between atropisomeric
diphosphines and ruthenium is a powerful tool for producing chiral compounds. Using a …

An asymmetric hydrosilylation of α-oxygenated ketones was developed under the catalysis
of Co (OAc) 2 in combination with a chiral phosphine-amido-oxazoline (PAO) ligand …

A series of seleno-containing polyfunctionalized compounds was synthesized exploring
cyanohydrin chemistry, including α-hydroxy esters, α-hydroxy acids, 1, 2-diols, and 1, 2 …

A molecularly defined chiral boxmi iron alkyl complex catalyzes the hydroboration of various
functionalized ketones and provides the corresponding chiral halohydrines, oxaheterocycles …

The α-hydroxymethyl ketone motif has been widely found in many pharmaceutically
important molecules and used as a key intermediate in the synthesis of various fine …

Polymer-supported chiral ligands 9 and 17 were prepared based on Noyori's (1S, 2S)-or
(1R, 2R)-N-(p-tolylsulfonyl)-1, 2-diphenylethylenediamine. The combination with [RuCl2 (p …